Product Information

Bulk Quantities of recombinant human (B2M) Beta 2-microglobulin from 1-10 gram single lot sizes. Custom fills for recombinant (B2M) beta-2-microglobulin available.

Class I MHC molecules consist of two separate polypeptide chains. The class I alpha chain is an MHC-encoded , transmembrane polypeptide containing three extracellular domains as referred to alpha1, alpha2, and alpha3. The second polypeptide chain is a non-MHC-encoded, 12 kDa polypeptide called beta-2-microglobulin. Since beta-2-microglobulin (B2M) does not contain a transmembrane domain, it associates with a chain through non-covalent interaction. This interaction is important for the stability of the MHC class I structure, its peptide-loading and its ability to present peptide antigen to CD8+ T cells.

beta-2-microglobulin r-hB2M is produced as an inclusion body in E. coli by expressing gene encoding human beta-2-microglobulin (B2M). From the inclusion body, recombinant human beta-2-microglobulin rB2M is refolded and treated by CNBr cleavage to show identical amino acid sequence to native one from human tissue origin.

beta-2-microglobulin Application: In vitro extension of amyloid fibrils, High qualified antigen for antibody production

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Price: $195.00

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