QUANTITY: 25 mg
CONCENTRATION: 0.5 mg/ml
Molecular Structure: A soluble fusion protein consisting of the extracellular (175aa) domain of human CD95 fused to human IgG1 Fc (234aa).
Transfectant Cell Line: CHO
INFORMATION: Human CD95 (APO-1/FAS) is a type I cell surface glycoprotein that is strongly upregulated on activated T cells, B cells, NK cells and thymocytes (1). CD95 plays an important role in programmed cell death or apoptosis (2). Apoptosis appears to be a mechanism for regulating the immune response (3, 4). CD95-huIg fusion protein blocks binding of anti-human CD95 antibody to cells expressing CD95.
References: (1). Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford (1995) p. 1142-1148. (2). S. Nagata & P. Golstein (1995) Science 267: 1449-1456. (3). S. Nagata & T. Suda (1995) Immunol Today 16: 39-43. (4). D.H. Lynch, F. Ramsdell & M.R. Alderson (1995) Immunol Today 16: 569-574.
STORAGE CONDITIONS: Store at 2 - 5oC. Freeze/Thawing is not recommended.
PRODUCT STABILITY: Product should retain activity for at least 12 months after shipping date when stored as recommended.
BUFFER: 50 mM Sodium Phosphate pH 7.5, 100 mM Potassium Chloride, 150mM NaCl, 0.5mg/ml Gentamicin Sulfate (as a preservative).
PRODUCTION: CD95-huIg fusion protein was Protein A purified from (low FBS containing) tissue culture supernatant of CHO transfectants. Purity was >95% by SDS-PAGE with less than 1% Bovine Immunoglobulin.
/Human Proteins/Human CD95(APO-1/FasR)-huIg Fusion Protein
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